Ability of the electrocardiogram to detect myocardial. The inflammatory responses play a major role in the pathogenesis of acute myocardial infarction mi. Mi is an important acute disease of myocardial tissue caused by an imbalance between myocardial blood demand and the coronary blood delivery, leading to cardiac ischemia, degeneration of. Thus, we aimed to investigate the cardio protective effects of ast on isoproterenolinduced myocardial infarction in rats. Origination and development of isoproterenol induced myocardial infarction in male wistar rats. Our study is aimed at evaluating the effects of pretreatment with curcumin nanoparticles ccnp compared to conventional curcumin cc on isoproterenol iso induced myocardial infarction mi in rats. As it has been reported that isoproterenol can cause ischemic myocardial alterations, lipid peroxide generation and procoagulant activity, we administered it to rabbits in order to induce a noninvasive myocardial infarction associated with above mentioned.
In this research, we aim to evaluate the cardioprotective effects of puerarinv on the isoproterenol iso induced mi mice and elucidate the underlying mechanisms. The effect of curcumin on the biochemical changes induced by isoproterenol iso administration in rats was examined. Luteolin7diglucuronide attenuates isoproterenolinduced. Pdf origination and development of isoproterenolinduced. The above results indicate the cardioprotective effect of mangiferin against isphinduced myocardial infarction in rats.
Pdf evaluation of cardioprotective role of vinpocetine. Heart failure, hypertrophy and myocardial ischemia will occur due to the. Cardio protective role of wogonin loaded nanoparticle. Curcumin from curcuma longa is a nutraceutical compound reported to possess strong antioxidant activity that makes it a candidate for use in counteracting oxidative stressinduced damage.
Pdf experimental model of myocardial infarction induced. To evaluate and validate, in our laboratory, the essay of myocardial infarction induced by isoproterenol in rats by means of analysis of hematological, biochemical, oxidative stress markers and histopathological parameters. Bolboaca 2 1department of pathophysiology, iuliu hatieganu university of medicine and pharmacy clujnapoca, 400012 clujnapoca, romania. Isoproterenol injections alone caused the expected cardiotoxicity. Blood and tissue samples liver, brain, adrenal glands, normal and necrotic areas of the heart were collected 15, 30, and 45 minutes after tracer injection.
Author links open overlay panel wan bei li jing nie chen. Alprazolam decreases isoproterenol induced myocardial. Isoproterenol induced myocardial infarction in rat heart, which was significantly prevented by camellia sinensis and carvedilol treatment alone and in combination. This study dealt with the protective role of walnut kernels extracts wk on isoproterenol isoinduced myocardial infarction mi in rats. Myocardial infarction mi is a condition in which a part of the heart muscle suddenly loses its blood supply, so the myocardium gets. This study was designed to scientifically evaluate the effects of an aqueous extract of muntingia calabura l. Cardioprotective effects of puerarinv on isoproterenolinduced. The study was designed to evaluate the antioxidant potential of eriodictyol on lipid peroxidation caused due to isoproterenol induced myocardial infarction in albino male wistar rats.
The present study in rats demonstrates that diffuse isoproterenolinduced myocardial necrosis results in a progressive enlargement of the lv cavity that is out of proportion to mass, a finding similar to that observed in discrete myocardial infarction. Preventive effect of nerolidol on isoproterenol induced. Cardioprotective effects of rosmarinic acid on isoproterenol. The present study was designed to evaluate the cardioprotective effects of lagenaria siceraria fruit juice in isoproterenolinduced myocardial infarction.
Effect of gonadectomy on isoproterenolinduced myocardial. Chronic myocardial infarction cmi the chronic myocardial infarction was induced by intraperitoneal. Effect of luteolin on lipid peroxidation and antioxidants. The rats were randomly divided into five groups, each group consisting of six rats. Abstractthis study was designed to investigate the cardioprotective effect of sesamol on isoproterenol isoinduced myocardial infarction in adult male. Isoprenaline, or isoproterenol, is a medication used for the treatment of bradycardia slow heart rate, heart block, and rarely for asthma. Cardio protective role of wogonin loaded nanoparticle against isoproterenol induced myocardial infarction by moderating oxidative stress and inflammation. Pdf isoproterenolinduced myocardial infarction in wistar rats. Effect of vitamin d on isoprenalineinduced myocardial. Preclinical studies as well as several clinical studies showed that during ischemic damage, oxidative stress produced by the generation of reactive oxygen species ros plays a key role in the development. Myocardial infarction was induced by subcutaneous injection of isoproterenol 100 mgkg once daily for 2. Curcumin has antiinflammatory, antioxidative, anticarcinogenic, and cardiovascular protective effects.
Our study is aimed at evaluating the effects of pretreatment with polylactic. Two hundred mgkg iso dose was selected for the present study as this dose. Wistar strain rats were pretreated with oa 20, 40, and 60 mgkg, s. Rats were pretreated with wk extracts 300 mgkg daily for 35 days. The mi was induced on day using 100 mgkg bw iso administered twice, with. Effects of curcumin nanoparticles in isoproterenolinduced. Myocardial infarction is usually induced in small animals by means of invasive techniques based on mechanical coronary obstruction.
Isoproterenol, isoprenaline, myocardial infarction, cardioprotective were used as keywords for the searching. Protective role of curcumin against isoproterenol induced. Isoproterenol iso, a synthetic catecholomine causes myocardial cell damage when administered in large doses 1, 2. Tacrolimus ameliorates functional disturbances and. A model of myocardial fibrosis and heart failure was established by oncedaily subcutaneous. The present study aimed at investigating the protective effects of nerolidol nrd against myocardial infarction mi induced by isoproterenol iso in wistar rats. Luteolin7diglucuronide attenuates isoproterenolinduced myocardial injury and fibrosis in mice. Acute myocardial infarction is a leading cause of morbidity and mortality worldwide. Antiplatelet eff ects of nimesulide in isoproterenol. Protective effects of cardamom in isoproterenolinduced. Myocardial infarction was induced by subcutaneous injection of isoproterenol, 85 mgkg body weight after a pretreatment period of 45 days with eriodictyol in various doses 50 mg, 100 mg.
Astragaloside iv ast is a saponin from the roots of astragalus plants which has been widely used in traditional medicine to treat cardiovascular diseases. An evaluation of antioxidant potential of flavonoid. The control group, the kefir group 5 mlkgd kefir administered to rats as intragastric gavage for 60 d, the iso group 100 mgkg. L56, induced by the subcutaneous injection of isoproterenol hydrochloride solution 100 mgkg, and sacrificed over 6. Cardioprotective effects of lagenaria siceraria fruit. Panax ginseng is used widely for treatment of cardiovascular disorders in china. All national and international guidelines for the care and use of animals were closely followed. Shift in antioxidant parameters, lactate dehydrogenase ldh together with morphological and histopathological changes were investigated.
Myocardial infarction mi is characterized by an inequity of coronary blood supply and demand, which results in myocardial ischemic injury and damages the cardiomyocytes. Cardioprotective molecular mechanism of syringic acid against. Effects of heme oxygenase1 upregulation on isoproterenolinduced. Myocardial infarction mi is a leading cause of morbidity and is the primary cause of death in developed countries, despite rapid advancements made in the treatment strategies of ischemic heart disease 1,2. Isoproterenol iso administration induced the myocardial injury as evidenced by the altered ecg pattern with stsegment elevation and an increase in the levels of. Curcumin nanoparticles protect against isoproterenol. Vinpocetine is a phosphodiesterase type1 inhibitor having strong vasodilating effect through camp and cgmp elevation. The objective of this study was to determine whether d003 shows protective effects against isoinduced myocardial necrosis in rats. Pdf cardiovascular disease is considered the major cause of morbidity and mortality throughout the world. Isoproterenolinduced myocardial infarction in wistar rats. Protective effect of sesamol against myocardial infarction.
Interstitial fibrosis significantly was attenuated in treated groups compared with control mi group. Sixty rats were randomly divided into six groups of 10 rats each. Isoproterenol induced cardiac arrhythmias, myocardial damage and cardiac enlargement. Sham group, which underwent a virtual myocardial infarction induction, and. Artile investigation of the protective effect of kefir. Acute myocardial infarction ami the acute myocardial infarction was induced by intraperitoneal i. Thirty young, male, wistar rats 145 to 230 g were randomly allocated in two groups. Effect of calotropis procera latex on isoproterenol induced myocardial infarction in albino rats. Tacrolimus ameliorates functional disturbances and oxidative stress in isoproterenolinduced myocardial infarction arash khorrami1,2, mojtaba hammami2, mehraveh garjani2, nasrin malekidizaji1 and alireza garjani1 abstract background. Cardioprotective effect of paeonol and danshensu combination on.
Cardioprotective effect of mangiferin on isoproterenol. Male wistar rats were assigned to 5 groups of control, isoproterenol, and treatments with 10, 20, 40 mgkg of rosmarinic acid. Beneficial role of tamoxifen in isoproterenolinduced. Adult male and female spraguedawley rats were subjected to an isopro terenol induced myocardial infarction. This study was designed to investigate the protective effect of oleanolic acid oa against isoproterenolinduced myocardial ischemia in rat myocardium. Isoproterenol iso, a synthetic catecholamine and betaadrenergic agonist, has been found to produce mi in large doses due to generation of. Myocardial trauma and damage were induced by two doses of isoproterenol 40 mgkg. Cardioprotective potential of punica granatum extract in isoproterenolinduced myocardial infarction in wistar rats. Cardiac lesions induced by isoproterenol iso are characterized by myocardial necrosis and exudative infiltration. To investigate the cardioprotective role of methanolic extract, myocardial infarction mi was induced in rats using isoproterenol. Ischemic heart diseases ihd remain the principal cause of death in both developed and developing countries, accounting for about 20% of death per year worldwide 1. Rosmarinic acid is a polyphenolic compound with considerable antioxidant activities.
Isoproterenolinduced myocardial injury and diastolic. The levels of inflammatory marker ldh, cardiac markers crp, troponint, ckmb, lipid peroxidase activity were restored to normal levels in. Isoproterenol, lipid peroxides, mangiferin, marker enzymes, myocardial infarction myocardial infarction mi is the acute condition of necrosis of the myocardium that occurs as a result of. Then, iso 100 mgkg was injected subcutaneously into rats to induce mi.
Ability of the electrocardiogram to detect myocardial lesions in isoproterenol induced rat cardiomyopathy reinaldo b bestetti. The rats were randomly divided into 4 groups, each group consisting of 8 rats. Experimental model of myocardial infarction induced by. The effect of astragaloside iv on isoproterenolinduced. Mature male rats with isoproterenolinduced myocardial infarction and normal controls were injected intravenously with 1, 23 h corticosterone 3 h corticosterone. Isoproterenolinduced myocardial infarction in rabbits. View the article pdf and any associated supplements and figures for a period of 48 hours. Thus, we aimed to investigate the cardio protective effects of ast on isoproterenol induced myocardial infarction in rats. Ginsenoside re is the main chemical component of p. Vasodilators may play positive role in myocardial infarction mi.
We aimed to investigate the protective effect of ginsenoside re on isoproterenolinduced myocardial fibrosis and heart failure in rats. Preventive effect of agnucastoside c against isoproterenol. Platelet aggregation was induced with arachidonic acid aa and platelet activating factor paf, and monitored by. Research article effects of curcumin nanoparticles in isoproterenolinduced myocardial infarction paulmihai boarescu,1,2 ioana chirila,3 adriana e. Blood and tissue samples liver, brain, adrenal glands, normal and necrotic areas of the heart were collected 15, 30, and 45. Effects of histidine and vitamin c on isoproterenol. Cardioprotective effect of oleanolic acid on isoproterenol. We aimed to investigate its cardioprotective effects against isoproterenolinduced myocardial infarction mi in rats. The mechanism might be associated with the enhancement of antioxidant defense system through activating of nrf2 signaling and antiapoptosis through regulating bax, bcl2 and caspase3. Several hypotheses have been postulated to explain pathophysiology of the myocardial injury in isoinduced mi such as relative myocardial. However, the effect of ast on myocardial infarction remains unknown. Because of its cardiac stimulatory action it may increase systolic blood pressure slightly, but it reduces mean arterial and diastolic blood pressure. Fiftysix wistarbratislava white rats were randomly divided into eight groups of seven. However, the cardioprotective effects of puerarinv on myocardial infarction mi heart failure are still unclear.
Isoproterenolinduced myocardial infarction in rats. This study demonstrates the cardioprotective effect of paeonol and danshensu combination on isoproterenolinduced myocardial infarction in rats. Advanced glycation end products in isoproterenolinduced. Myocardial infarction was induced by isoproterenol isp 65 mgkg and confi rmed by biochemical, electrophysiological and histopathological methods. A single subcutaneous injection of isoproterenol 85 mgkg results in a rapid, marked increase in infarctlike myocardial necrosis in rats. Isoproterenolinduced myocardial infarction in wistar rats article pdf available in journal of biomedicine and biotechnology 20166 may 2016 with 2,163 reads how we measure reads. Cardioprotective effects of puerarinv on isoproterenol.
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